Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concern on pig-to-human immunological compatibility, the risk of cross-species transmission of porcine endogenous retroviruses (PERVs) has impeded the clinical application of...

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Publicado no:Science
Main Authors: Niu, Dong, Wei, Hong-Jiang, Lin, Lin, George, Haydy, Wang, Tao, Lee, I-Hsiu, Zhao, Hong-Ye, Wang, Yong, Kan, Yinan, Shrock, Ellen, Lesha, Emal, Wang, Gang, Luo, Yonglun, Qing, Yubo, Jiao, Deling, Zhao, Heng, Zhou, Xiaoyang, Wang, Shouqi, Wei, Hong, Güell, Marc, Church, George M., Yang, Luhan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813284/
https://ncbi.nlm.nih.gov/pubmed/28798043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan4187
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