Engineering and optimising deaminase fusions for genome editing

Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could intr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yang, Luhan, Briggs, Adrian W., Chew, Wei Leong, Mali, Prashant, Guell, Marc, Aach, John, Goodman, Daniel Bryan, Cox, David, Kan, Yinan, Lesha, Emal, Soundararajan, Venkataramanan, Zhang, Feng, Church, George
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097136/
https://ncbi.nlm.nih.gov/pubmed/27804970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13330
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