The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

A hallmark of macroautophagy is the covalent lipidation of LC3 and insertion into the double‐membrane phagophore, which is driven by the ATG16L1/ATG5‐ATG12 complex. In contrast, non‐canonical autophagy is a pathway through which LC3 is lipidated and inserted into single membranes, particularly endol...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Fletcher, Katherine, Ulferts, Rachel, Jacquin, Elise, Veith, Talitha, Gammoh, Noor, Arasteh, Julia M, Mayer, Ulrike, Carding, Simon R, Wileman, Thomas, Beale, Rupert, Florey, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813257/
https://ncbi.nlm.nih.gov/pubmed/29317426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797840
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