Analytical Validation and Application of a Targeted Next-Generation Sequencing Mutation-Detection Assay for Use in Treatment Assignment in the NCI-MPACT Trial

Robust and analytically validated assays are essential for clinical studies. We outline an analytical validation study of a targeted next-generation sequencing mutation-detection assay used for patient selection in the National Cancer Institute Molecular Profiling–Based Assignment of Cancer Therapy...

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Publicado no:J Mol Diagn
Main Authors: Lih, Chih-Jian, Sims, David J., Harrington, Robin D., Polley, Eric C., Zhao, Yingdong, Mehaffey, Michele G., Forbes, Thomas D., Das, Biswajit, Walsh, William D., Datta, Vivekananda, Harper, Kneshay N., Bouk, Courtney H., Rubinstein, Lawrence V., Simon, Richard M., Conley, Barbara A., Chen, Alice P., Kummar, Shivaani, Doroshow, James H., Williams, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812775/
https://ncbi.nlm.nih.gov/pubmed/26602013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2015.07.006
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