Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms

Osteomyelitis is a major problem worldwide and is devastating due to the potential for limb-threatening sequelae and mortality. Osteomyelitis pathogens are bone-attached biofilms, making antibiotic delivery challenging. Here we describe a novel osteoadsorptive bisphosphonate-ciprofloxacin conjugate...

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Vydáno v:J Med Chem
Hlavní autoři: Sedghizadeh, Parish P., Sun, Shuting, Junka, Adam F., Richard, Eric, Sadrerafi, Keivan, Mahabady, Susan, Bakhshalian, Neema, Tjokro, Natalia, Bartoszewicz, Marzenna, Oleksy, Monika, Szymczyk, Patrycja, Lundy, Mark W., Neighbors, Jeffrey D., Russell, R. Graham G., McKenna, Charles E., Ebetino, Frank H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812453/
https://ncbi.nlm.nih.gov/pubmed/28121436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01615
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