Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms

Osteomyelitis is a major problem worldwide and is devastating due to the potential for limb-threatening sequelae and mortality. Osteomyelitis pathogens are bone-attached biofilms, making antibiotic delivery challenging. Here we describe a novel osteoadsorptive bisphosphonate-ciprofloxacin conjugate...

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Publicado no:J Med Chem
Main Authors: Sedghizadeh, Parish P., Sun, Shuting, Junka, Adam F., Richard, Eric, Sadrerafi, Keivan, Mahabady, Susan, Bakhshalian, Neema, Tjokro, Natalia, Bartoszewicz, Marzenna, Oleksy, Monika, Szymczyk, Patrycja, Lundy, Mark W., Neighbors, Jeffrey D., Russell, R. Graham G., McKenna, Charles E., Ebetino, Frank H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812453/
https://ncbi.nlm.nih.gov/pubmed/28121436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01615
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