C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease caused by recurrent mutations in the transcription regulatory machinery, resulting in abnormal growth and a block in differentiation. One type of recurrent mutations affects RUNX1, which is subject to mutations and translocations, the latter gi...

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Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Loke, Justin, Chin, Paulynn Suyin, Keane, Peter, Pickin, Anna, Assi, Salam A., Ptasinska, Anetta, Imperato, Maria Rosaria, Cockerill, Peter N., Bonifer, Constanze
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812331/
https://ncbi.nlm.nih.gov/pubmed/29431622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017012781
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