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Detecting RNA base methylations in single cells by in situ hybridization
Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein synthesis, antimicrobial resistance and gene expression. Currently, bulk methods that report the average methylation state of ~10(4)–10(7) cells are used to detect these modifications, obscuring potent...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811446/ https://ncbi.nlm.nih.gov/pubmed/29440632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02714-7 |
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