Detecting RNA base methylations in single cells by in situ hybridization

Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein synthesis, antimicrobial resistance and gene expression. Currently, bulk methods that report the average methylation state of ~10(4)–10(7) cells are used to detect these modifications, obscuring potent...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ranasinghe, Rohan T., Challand, Martin R., Ganzinger, Kristina A., Lewis, Benjamin W., Softley, Charlotte, Schmied, Wolfgang H., Horrocks, Mathew H., Shivji, Nadia, Chin, Jason W., Spencer, James, Klenerman, David
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811446/
https://ncbi.nlm.nih.gov/pubmed/29440632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02714-7
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