The impact of statin use on the efficacy of abiraterone acetate in patients with castration-resistant prostate cancer

BACKGROUND: Statins compete with DHEAS for influx through the SLCO2B1 transporter, which may prolong time to progression (TTP) on androgen deprivation therapy. Abiraterone acetate (AA) may also undergo SLCO-mediated transport. Based on preclinical findings showing antagonism, we hypothesized that st...

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Publié dans:Prostate
Auteurs principaux: Harshman, Lauren C., Werner, Lillian, Tripathi, Abhishek, Wang, Xiaodong, Maughan, Benjamin L., Antonarakis, Emmanuel S., Nakabayashi, Mari, McKay, Rana, Pomerantz, Mark, Mucci, Lorelei A., Taplin, Mary-Ellen, Sweeney, Christopher J., Lee, Gwo-Shu Mary, Kantoff, Philip W.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811259/
https://ncbi.nlm.nih.gov/pubmed/28762529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23390
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