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A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition
Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft, a key step in neurotransmission, which is targeted in the treatment of neurological disorders. Cholesterol (CHOL), a major component of the synaptic plasma membrane, has been shown to exhibit a modulatory effe...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811071/ https://ncbi.nlm.nih.gov/pubmed/29329285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005907 |
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