SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

BACKGROUND: SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia. SF3B1 mutations have been implicated in the path...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Huang, Yumin, Hale, John, Wang, Yaomei, Li, Wei, Zhang, Shijie, Zhang, Jieying, Zhao, Huizhi, Guo, Xinhua, Liu, Jing, Yan, Hongxia, Yazdanbakhsh, Karina, Huang, Gang, Hillyer, Christopher D., Mohandas, Narla, Chen, Lixiang, Sun, Ling, An, Xiuli
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810112/
https://ncbi.nlm.nih.gov/pubmed/29433555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0558-8
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