SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

BACKGROUND: SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia. SF3B1 mutations have been implicated in the path...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Hematol Oncol
Prif Awduron: Huang, Yumin, Hale, John, Wang, Yaomei, Li, Wei, Zhang, Shijie, Zhang, Jieying, Zhao, Huizhi, Guo, Xinhua, Liu, Jing, Yan, Hongxia, Yazdanbakhsh, Karina, Huang, Gang, Hillyer, Christopher D., Mohandas, Narla, Chen, Lixiang, Sun, Ling, An, Xiuli
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2018
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810112/
https://ncbi.nlm.nih.gov/pubmed/29433555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0558-8
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