SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

BACKGROUND: SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia. SF3B1 mutations have been implicated in the path...

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Bibliografski detalji
Izdano u:J Hematol Oncol
Glavni autori: Huang, Yumin, Hale, John, Wang, Yaomei, Li, Wei, Zhang, Shijie, Zhang, Jieying, Zhao, Huizhi, Guo, Xinhua, Liu, Jing, Yan, Hongxia, Yazdanbakhsh, Karina, Huang, Gang, Hillyer, Christopher D., Mohandas, Narla, Chen, Lixiang, Sun, Ling, An, Xiuli
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810112/
https://ncbi.nlm.nih.gov/pubmed/29433555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0558-8
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