Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR)...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Yuan, Xunmei, Tsujimoto, Kazutaka, Hashimoto, Koshi, Kawahori, Kenichi, Hanzawa, Nozomi, Hamaguchi, Miho, Seki, Takami, Nawa, Makiko, Ehara, Tatsuya, Kitamura, Yohei, Hatada, Izuho, Konishi, Morichika, Itoh, Nobuyuki, Nakagawa, Yoshimi, Shimano, Hitoshi, Takai-Igarashi, Takako, Kamei, Yasutomi, Ogawa, Yoshihiro
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809372/
https://ncbi.nlm.nih.gov/pubmed/29434210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03038-w
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