Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR)...

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Publicat a:Nat Commun
Autors principals: Yuan, Xunmei, Tsujimoto, Kazutaka, Hashimoto, Koshi, Kawahori, Kenichi, Hanzawa, Nozomi, Hamaguchi, Miho, Seki, Takami, Nawa, Makiko, Ehara, Tatsuya, Kitamura, Yohei, Hatada, Izuho, Konishi, Morichika, Itoh, Nobuyuki, Nakagawa, Yoshimi, Shimano, Hitoshi, Takai-Igarashi, Takako, Kamei, Yasutomi, Ogawa, Yoshihiro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809372/
https://ncbi.nlm.nih.gov/pubmed/29434210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03038-w
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