Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Ex vivo systems that incorporate features of the tumor microenvironment (TME) and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision immuno-oncology and the development of effective combination therapies. Here, we demonstrate the ability to interrogate...

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Publicado no:Cancer Discov
Main Authors: Jenkins, Russell W., Aref, Amir R., Lizotte, Patrick H., Ivanova, Elena, Stinson, Susanna, Zhou, Chensheng W., Bowden, Michaela, Deng, Jiehui, Liu, Hongye, Miao, Diana, He, Meng Xiao, Walker, William, Zhang, Gao, Tian, Tian, Cheng, Chaoran, Wei, Zhi, Palakurthi, Sangeetha, Bittinger, Mark, Vitzthum, Hans, Kim, Jong Wook, Merlino, Ashley, Quinn, Max, Venkataramani, Chandrasekar, Kaplan, Joshua A., Portell, Andrew, Gokhale, Prafulla C., Phillips, Bart, Smart, Alicia, Rotem, Asaf, Jones, Robert E., Keogh, Lauren, Anguiano, Maria, Stapleton, Lance, Jia, Zhiheng, Barzily-Rokni, Michal, Cañadas, Israel, Thai, Tran C., Hammond, Marc R., Vlahos, Raven, Wang, Eric S., Zhang, Hua, Li, Shuai, Hanna, Glenn J., Huang, Wei, Hoang, Mai P., Piris, Adriano, Eliane, Jean-Pierre, Stemmer-Rachamimov, Anat O., Cameron, Lisa, Su, Mei-Ju, Shah, Parin, Izar, Benjamin, Thakuria, Manisha, LeBoeuf, Nicole R., Rabinowits, Guilherme, Gunda, Viswanath, Parangi, Sareh, Cleary, James M., Miller, Brian C., Kitajima, Shunsuke, Thummalapalli, Rohit, Miao, Benchun, Barbie, Thanh U., Sivathanu, Vivek, Wong, Joshua, Richards, William G., Bueno, Raphael, Yoon, Charles H., Miret, Juan, Herlyn, Meenhard, Garraway, Levi A., Van Allen, Eliezer M., Freeman, Gordon J., Kirschmeier, Paul T., Lorch, Jochen H., Ott, Patrick A., Hodi, F. Stephen, Flaherty, Keith T., Kamm, Roger D., Boland, Genevieve M., Wong, Kwok-Kin, Dornan, David, Paweletz, Cloud Peter, Barbie, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809290/
https://ncbi.nlm.nih.gov/pubmed/29101162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0833
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