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A phase I study of tivantinib in combination with temsirolimus in patients with advanced solid tumors
BACKGROUND: A wide variety of human cancers exhibit dysregulated c-Met activity that has implications in oncogenesis. Phosphorylation of c-Met results in activation of the PI3K/AKT/mTOR pathway. Combined blockade of c-Met and mTOR pathways has shown efficacy in preclinical studies. Tivantinib is a c...
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| Publicado no: | Invest New Drugs |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5809175/ https://ncbi.nlm.nih.gov/pubmed/28004284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-016-0418-8 |
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