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Distinct pH dependencies of Na(+)/K(+) selectivity at the two faces of Na,K-ATPase

The sodium pump (Na,K-ATPase) in animal cells is vital for actively maintaining ATP hydrolysis–powered Na(+) and K(+) electrochemical gradients across the cell membrane. These ion gradients drive co- and countertransport and are critical for establishing the membrane potential. It has been an enigma...

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Vydáno v:J Biol Chem
Hlavní autoři: Cornelius, Flemming, Tsunekawa, Naoki, Toyoshima, Chikashi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808778/
https://ncbi.nlm.nih.gov/pubmed/29247005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000700
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