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A Structural View on the Functional Importance of the Sugar Moiety and Steroid Hydroxyls of Cardiotonic Steroids in Binding to Na,K-ATPase

The Na,K-ATPase is specifically inhibited by cardiotonic steroids (CTSs) like digoxin and is of significant therapeutic value in the treatment of congestive heart failure and arrhythmia. Recently, new interest has arisen in developing Na,K-ATPase inhibitors as anticancer agents. In the present study...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cornelius, Flemming, Kanai, Ryuta, Toyoshima, Chikashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585100/
https://ncbi.nlm.nih.gov/pubmed/23341448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.442137
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