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Enhancer Redundancy Allows for Phenotypic Robustness in Mammalian Development

Distant-acting tissue-specific enhancers vastly outnumber protein-coding genes in mammalian genomes, but the functional significance of this regulatory complexity remains insufficiently understood(1,2). Here we show that the pervasive presence of multiple enhancers with similar activities near the s...

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發表在:Nature
Main Authors: Osterwalder, Marco, Barozzi, Iros, Tissières, Virginie, Fukuda-Yuzawa, Yoko, Mannion, Brandon J., Afzal, Sarah Y., Lee, Elizabeth A., Zhu, Yiwen, Plajzer-Frick, Ingrid, Pickle, Catherine S., Kato, Momoe, Garvin, Tyler H., Pham, Quan T., Harrington, Anne N., Akiyama, Jennifer A., Afzal, Veena, Lopez-Rios, Javier, Dickel, Diane E., Visel, Axel, Pennacchio, Len A.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808607/
https://ncbi.nlm.nih.gov/pubmed/29420474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25461
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