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Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists
[Image: see text] Farnesoid X receptor (FXR) plays a major role in the control of cholesterol metabolism. Antagonizing transcriptional activity of FXR is an effective means to treat the relevant metabolic syndrome. Some of antagonists so far have the charged functions; however, they may negatively a...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Med Chem Lett |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2018
|
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807871/ https://ncbi.nlm.nih.gov/pubmed/29456791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00363 |
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