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Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor

TGR5 is a G protein-coupled receptor that is activated by bile acids, resulting in an increase in cAMP levels and the subsequent modulation of energy expenditure in brown adipose tissue and muscle. Therefore, the development of a TGR5-specific agonist could lead to the prevention and treatment of va...

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מידע ביבליוגרפי
Main Authors: Iguchi, Yusuke, Yamaguchi, Masafumi, Sato, Hiroyuki, Kihira, Kenji, Nishimaki-Mogami, Tomoko, Une, Mizuho
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035506/
https://ncbi.nlm.nih.gov/pubmed/20023205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004051
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