Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

[Image: see text] Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Sammons, Matthew F., Kharade, Sujay V., Filipski, Kevin J., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Fernando, Dilinie P., Dowling, Matthew S., Carpino, Philip A., Castle, Neil A., Zellmer, Shannon G., Antonio, Brett M., Gosset, James R., Carlo, Anthony, Denton, Jerod S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2018
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807870/
https://ncbi.nlm.nih.gov/pubmed/29456800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00481
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