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Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1

[Image: see text] Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays an important role in triglyceride synthesis and is a target of interest for the treatment of metabolic disorders. Herein we describe the structure–activity relationship of a novel tetralone series of DGAT1 inhibitors and our s...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Cheung, Mui, Tangirala, Raghuram S., Bethi, Sridhar R., Joshi, Hemant V., Ariazi, Jennifer L., Tirunagaru, Vijaya G., Kumar, Sanjay
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807866/
https://ncbi.nlm.nih.gov/pubmed/29456796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00450
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