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Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1
[Image: see text] Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) plays an important role in triglyceride synthesis and is a target of interest for the treatment of metabolic disorders. Herein we describe the structure–activity relationship of a novel tetralone series of DGAT1 inhibitors and our s...
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| Publicado en: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical Society
2018
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807866/ https://ncbi.nlm.nih.gov/pubmed/29456796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00450 |
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