Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1

Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in mammalian triglyceride synthesis. DGAT1-deficient mice are resistant to diet-induced obesity through a mechanism involving increased energy expenditure. Here we show that these m...

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Main Authors: Chen, Hubert C., Smith, Steven J., Ladha, Zuleika, Jensen, Dalan R., Ferreira, Luis D., Pulawa, Leslie K., McGuire, James G., Pitas, Robert E., Eckel, Robert H., Farese, Robert V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150948/
https://ncbi.nlm.nih.gov/pubmed/11956242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14672
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