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Breaching self-tolerance to Alu duplex RNA underlies MDA5-mediated inflammation
Aberrant activation of innate immune receptors can cause a spectrum of immune disorders, such as Aicardi-Goutières syndrome (AGS). One such receptor is MDA5, a viral dsRNA sensor that induces antiviral immune response. Using a newly developed RNase protection/RNA-seq approach, we here demonstrate th...
Enregistré dans:
| Publié dans: | Cell |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807104/ https://ncbi.nlm.nih.gov/pubmed/29395326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.12.016 |
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