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Breaching self-tolerance by targeting the gatekeeper
Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to th...
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| 發表在: | J Exp Med |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Rockefeller University Press
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8047933/ https://ncbi.nlm.nih.gov/pubmed/33847707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20210322 |
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