Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage

Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adaptation that HIV-1 vaccine design seeks to mimic. To enable this, properties that render HIV-1 envelopes (Env) capable of eliciting bnAb responses need to be defined. Here,...

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Bibliografiska uppgifter
I publikationen:PLoS Pathog
Huvudupphovsmän: Reh, Lucia, Magnus, Carsten, Kadelka, Claus, Kühnert, Denise, Uhr, Therese, Weber, Jacqueline, Morris, Lynn, Moore, Penny L., Trkola, Alexandra
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806907/
https://ncbi.nlm.nih.gov/pubmed/29370298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006825
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