Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality

A hallmark of HIV-1 infection is the continuously declining number of the virus’ predominant target cells, activated CD4(+) T cells. With diminishing CD4(+) T cell levels, the capacity to utilize alternate cell types and receptors, including cells that express low CD4 receptor levels such as macroph...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Beauparlant, David, Rusert, Peter, Magnus, Carsten, Kadelka, Claus, Weber, Jacqueline, Uhr, Therese, Zagordi, Osvaldo, Oberle, Corinna, Duenas-Decamp, Maria J., Clapham, Paul R., Metzner, Karin J., Günthard, Huldrych F., Trkola, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354460/
https://ncbi.nlm.nih.gov/pubmed/28264054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006255
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