Acute Kynurenine Challenge Disrupts Sleep–Wake Architecture and Impairs Contextual Memory in Adult Rats

STUDY OBJECTIVES: Tryptophan metabolism via the kynurenine pathway may represent a key molecular link between sleep loss and cognitive dysfunction. Modest increases in the kynurenine pathway metabolite kynurenic acid (KYNA), which acts as an antagonist at N-methyl-d-aspartate and α7 nicotinic acetyl...

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Publicat a:Sleep
Autors principals: Pocivavsek, Ana, Baratta, Annalisa M, Mong, Jessica A, Viechweg, Shaun S
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Basic Science of Sleep and Circadian Rhythms
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806560/
https://ncbi.nlm.nih.gov/pubmed/29029302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsx141
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