Acute Kynurenine Challenge Disrupts Sleep–Wake Architecture and Impairs Contextual Memory in Adult Rats

STUDY OBJECTIVES: Tryptophan metabolism via the kynurenine pathway may represent a key molecular link between sleep loss and cognitive dysfunction. Modest increases in the kynurenine pathway metabolite kynurenic acid (KYNA), which acts as an antagonist at N-methyl-d-aspartate and α7 nicotinic acetyl...

Full description

Saved in:
Bibliographic Details
Published in:Sleep
Main Authors: Pocivavsek, Ana, Baratta, Annalisa M, Mong, Jessica A, Viechweg, Shaun S
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Basic Science of Sleep and Circadian Rhythms
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806560/
https://ncbi.nlm.nih.gov/pubmed/29029302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/sleep/zsx141
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items