Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys

BACKGROUND: Previous studies showed that the majority of developmental genes are devoid of DNA methylation at promoters even when they are repressed. Such hypomethylated regions at developmental genes are unusually large and extend well beyond proximal promoters, forming DNA methylation valleys (DMV...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Li, Yuanyuan, Zheng, Hui, Wang, Qiujun, Zhou, Chen, Wei, Lei, Liu, Xuehui, Zhang, Wenhao, Zhang, Yu, Du, Zhenhai, Wang, Xiaowo, Xie, Wei
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806489/
https://ncbi.nlm.nih.gov/pubmed/29422066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1390-8
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