Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys

BACKGROUND: Previous studies showed that the majority of developmental genes are devoid of DNA methylation at promoters even when they are repressed. Such hypomethylated regions at developmental genes are unusually large and extend well beyond proximal promoters, forming DNA methylation valleys (DMV...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Li, Yuanyuan, Zheng, Hui, Wang, Qiujun, Zhou, Chen, Wei, Lei, Liu, Xuehui, Zhang, Wenhao, Zhang, Yu, Du, Zhenhai, Wang, Xiaowo, Xie, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806489/
https://ncbi.nlm.nih.gov/pubmed/29422066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1390-8
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