Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys

BACKGROUND: Previous studies showed that the majority of developmental genes are devoid of DNA methylation at promoters even when they are repressed. Such hypomethylated regions at developmental genes are unusually large and extend well beyond proximal promoters, forming DNA methylation valleys (DMV...

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Опубликовано в: :Genome Biol
Главные авторы: Li, Yuanyuan, Zheng, Hui, Wang, Qiujun, Zhou, Chen, Wei, Lei, Liu, Xuehui, Zhang, Wenhao, Zhang, Yu, Du, Zhenhai, Wang, Xiaowo, Xie, Wei
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5806489/
https://ncbi.nlm.nih.gov/pubmed/29422066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1390-8
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