Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis

Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how various microenvironmental influences, such as hypoxia, contribute to their sustained activation and differentiation is...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Goodwin, Justin, Choi, Hyunsung, Hsieh, Meng-hsiung, Neugent, Michael L., Ahn, Jung-Mo, Hayenga, Heather N., Singh, Pankaj K., Shackelford, David B., Lee, In-Kyu, Shulaev, Vladimir, Dhar, Shanta, Takeda, Norihiko, Kim, Jung-whan
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805994/
https://ncbi.nlm.nih.gov/pubmed/28915065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0186OC
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