Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis

Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how various microenvironmental influences, such as hypoxia, contribute to their sustained activation and differentiation is...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Goodwin, Justin, Choi, Hyunsung, Hsieh, Meng-hsiung, Neugent, Michael L., Ahn, Jung-Mo, Hayenga, Heather N., Singh, Pankaj K., Shackelford, David B., Lee, In-Kyu, Shulaev, Vladimir, Dhar, Shanta, Takeda, Norihiko, Kim, Jung-whan
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805994/
https://ncbi.nlm.nih.gov/pubmed/28915065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0186OC
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