A phase Ib study of everolimus combined with metformin for patients with advanced cancer

Background The efficacy to monotherapy with the mTOR inhibitor everolimus in advanced cancer is often limited due to therapy resistance. Combining everolimus with metformin may decrease the chance of therapy resistance. Methods Patients received everolimus and metformin in a 3 + 3 dose-escalation sc...

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Udgivet i:Invest New Drugs
Main Authors: Molenaar, Remco J., van de Venne, Tim, Weterman, Mariëtte J., Mathot, Ron A., Klümpen, Heinz-Josef, Richel, Dick J., Wilmink, Johanna W.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2017
Fag:
Phase I Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805805/
https://ncbi.nlm.nih.gov/pubmed/28616837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-017-0478-4
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