Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice

A hallmark of acute promyelocytic leukemia (APL) is altered nuclear architecture, with disruption of promyelocytic leukemia (PML) nuclear bodies (NBs) mediated by the PML–retinoic acid receptor α (RARα) oncoprotein. To address whether this phenomenon plays a role in disease pathogenesis, we generate...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Voisset, Edwige, Moravcsik, Eva, Stratford, Eva W., Jaye, Amie, Palgrave, Christopher J., Hills, Robert K., Salomoni, Paolo, Kogan, Scott C., Solomon, Ellen, Grimwade, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805489/
https://ncbi.nlm.nih.gov/pubmed/29191918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-07-794784
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