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RNA interference-based functional knockdown of the voltage-gated potassium channel Kv7.2 in dorsal root ganglion neurons after in vitro and in vivo gene transfer by adeno-associated virus vectors

Activation of the neuronal potassium channel Kv7.2 encoded by the KCNQ2 gene has recently been shown to be an attractive mechanism to inhibit nociceptive transmission. However, potent, selective, and clinically proven activators of Kv7.2/Kv7.3 currents with analgesic properties are still lacking. An...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Pain
Κύριοι συγγραφείς: Valdor, Markus, Wagner, Anke, Röhrs, Viola, Berg, Johanna, Fechner, Henry, Schröder, Wolfgang, Tzschentke, Thomas M, Bahrenberg, Gregor, Christoph, Thomas, Kurreck, Jens
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: SAGE Publications 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805000/
https://ncbi.nlm.nih.gov/pubmed/29212407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917749669
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