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Targeting the voltage sensor of Kv7.2 voltage-gated K(+) channels with a new gating-modifier
The pore and gate regions of voltage-gated cation channels have been often targeted with drugs acting as channel modulators. In contrast, the voltage-sensing domain (VSD) was practically not exploited for therapeutic purposes, although it is the target of various toxins. We recently designed unique...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2932606/ https://ncbi.nlm.nih.gov/pubmed/20713704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911294107 |
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