Targeting the voltage sensor of Kv7.2 voltage-gated K(+) channels with a new gating-modifier

The pore and gate regions of voltage-gated cation channels have been often targeted with drugs acting as channel modulators. In contrast, the voltage-sensing domain (VSD) was practically not exploited for therapeutic purposes, although it is the target of various toxins. We recently designed unique...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Peretz, Asher, Pell, Liat, Gofman, Yana, Haitin, Yoni, Shamgar, Liora, Patrich, Eti, Kornilov, Polina, Gourgy-Hacohen, Orit, Ben-Tal, Nir, Attali, Bernard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932606/
https://ncbi.nlm.nih.gov/pubmed/20713704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911294107
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