Targeted Delivery of the HLA-B(∗)27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis

Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B(∗)27). HLA-B(∗)27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the endoplasmic reticulum (ER) and formation of the HLA...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Yu, Hui-Chun, Huang, Kuang-Yung, Lu, Ming-Chi, Huang, Hsien-Lu, Liu, Su-Qin, Lai, Ning-Sheng, Huang, Hsien-Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804395/
https://ncbi.nlm.nih.gov/pubmed/29463951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4016802
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