Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

BACKGROUND: The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations. OBJECTIVES: Study the anti-Trypanosoma cruzi activity of associations of benznidazole (Bnz) with three n...

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Vydáno v:Mem Inst Oswaldo Cruz
Hlavní autoři: Aguilera, Elena, Varela, Javier, Serna, Elva, Torres, Susana, Yaluff, Gloria, de Bilbao, Ninfa Vera, Cerecetto, Hugo, Alvarez, Guzmán, González, Mercedes
Médium: Artigo
Jazyk:Inglês
Vydáno: Instituto Oswaldo Cruz, Ministério da Saúde 2018
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804306/
https://ncbi.nlm.nih.gov/pubmed/29412353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760170267
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