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Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain

Tyro3, a member of TAM receptor tyrosine kinase family, has been implicated in the regulation of melanoma progression and survival. In this study, we sought the molecular mechanism of Tyro3 effects avoiding endogenous background by overexpression of Tyro3 in fibroblasts that have negligible levels o...

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Detalhes bibliográficos
Publicado no:Int J Biochem Cell Biol
Main Authors: Shao, Hanshuang, Wang, Anna, Lauffenburger, Douglas, Wells, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803314/
https://ncbi.nlm.nih.gov/pubmed/29274473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2017.12.014
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