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The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K(+) stimulation but not cortical spreading depression-induced afferent sensitization

INTRODUCTION: Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. One putative mechanism underlying this afferent response involves an acute excitation of meningeal afferents by...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pain Rep
Hauptverfasser: Zhao, Jun, Levy, Dan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802320/
https://ncbi.nlm.nih.gov/pubmed/29430561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PR9.0000000000000632
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