Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators known. This peptide is increased during migraine attacks and has been implicated in the pathogenesis of migraine headache. Here we report on the first small molecule selective CGRP antagonist: BIBN4096BS. In vit...

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Библиографические подробности
Главные авторы: Doods, Henri, Hallermayer, Gerhard, Wu, Dongmei, Entzeroth, Michael, Rudolf, Klaus, Engel, Wolfhard, Eberlein, Wolfgang
Формат: Artigo
Язык:Inglês
Опубликовано: 2000
Предметы:
Special Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571877/
https://ncbi.nlm.nih.gov/pubmed/10711339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703110
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