Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness

The A1555G mutation in the 12S rRNA gene of human mitochondrial DNA causes maternally inherited, nonsyndromic deafness, an extreme case of tissue-specific mitochondrial pathology. A transgenic mouse strain that robustly overexpresses the mitochondrial 12S ribosomal RNA methyltransferase TFB1M (Tg-mt...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: McKay, Sharen E., Yan, Wayne, Nouws, Jessica, Thormann, Maximilian J., Raimundo, Nuno, Khan, Abdul, Santos-Sacchi, Joseph, Song, Lei, Shadel, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801480/
https://ncbi.nlm.nih.gov/pubmed/26552864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.014
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