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Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness
The A1555G mutation in the 12S rRNA gene of human mitochondrial DNA causes maternally inherited, nonsyndromic deafness, an extreme case of tissue-specific mitochondrial pathology. A transgenic mouse strain that robustly overexpresses the mitochondrial 12S ribosomal RNA methyltransferase TFB1M (Tg-mt...
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| 出版年: | Am J Pathol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Investigative Pathology
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5801480/ https://ncbi.nlm.nih.gov/pubmed/26552864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.08.014 |
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