Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness

Mitochondrial dysfunction causes poorly understood tissue-specific pathology stemming from primary defects in respiration, coupled with altered reactive oxygen species (ROS), metabolic signaling and apoptosis. The A1555G mtDNA mutation that causes maternally inherited deafness disrupts mitochondrial...

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Detaylı Bibliyografya
Asıl Yazarlar: Raimundo, Nuno, Song, Lei, Shutt, Timothy E., McKay, Sharen E., Cotney, Justin, Guan, Min-Xin, Gilliland, Thomas C., Hohuan, David, Santos-Sacchi, Joseph, Shadel, Gerald S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285425/
https://ncbi.nlm.nih.gov/pubmed/22341444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.12.027
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