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Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness
Mitochondrial dysfunction causes poorly understood tissue-specific pathology stemming from primary defects in respiration, coupled with altered reactive oxygen species (ROS), metabolic signaling and apoptosis. The A1555G mtDNA mutation that causes maternally inherited deafness disrupts mitochondrial...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285425/ https://ncbi.nlm.nih.gov/pubmed/22341444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.12.027 |
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