Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages

The generation of CD138(+) phagocytic macrophages with an alternative (M2) phenotype that clear apoptotic cells from tissues is defective in lupus. Liver X receptor-alpha (LXRα) is an oxysterol-regulated transcription factor that promotes reverse cholesterol transport and alternative (M2) macrophage...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Han, Shuhong, Zhuang, Haoyang, Shumyak, Stepan, Wu, Jingfan, Xie, Chao, Li, Hui, Yang, Li-Jun, Reeves, Westley H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801423/
https://ncbi.nlm.nih.gov/pubmed/29456535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00135
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