Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages

The generation of CD138(+) phagocytic macrophages with an alternative (M2) phenotype that clear apoptotic cells from tissues is defective in lupus. Liver X receptor-alpha (LXRα) is an oxysterol-regulated transcription factor that promotes reverse cholesterol transport and alternative (M2) macrophage...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Han, Shuhong, Zhuang, Haoyang, Shumyak, Stepan, Wu, Jingfan, Xie, Chao, Li, Hui, Yang, Li-Jun, Reeves, Westley H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801423/
https://ncbi.nlm.nih.gov/pubmed/29456535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00135
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