Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1

Multiple myeloma (MM) is a lethal haematological malignancy that arises in the context of a tumour microenvironment that promotes resistance to apoptosis and immune escape. In the present study, we demonstrate that co-culture of MM cells with stromal cells results in increased resistance to cytotoxi...

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Veröffentlicht in:Br J Haematol
Hauptverfasser: Bar-Natan, Michal, Stroopinsky, Dina, Luptakova, Katarina, Coll, Maxwell D., Apel, Arie, Rajabi, Hasan, Pyzer, Athalia R., Palmer, Kristen, Reagan, Michaela R., Nahas, Myrna R., Leaf, Rebecca Karp, Jain, Salvia, Arnason, Jon, Ghobrial, Irene M., Anderson, Kenneth C., Kufe, Donald, Rosenblatt, Jacalyn, Avigan, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800979/
https://ncbi.nlm.nih.gov/pubmed/28107546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14493
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