Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors

Aberrant activity of enhancer of zeste homolog 2 (EZH2) is associated with a wide range of human cancers. The interaction of EZH2 with embryonic ectoderm development (EED) is required for EZH2's catalytic activity. Inhibition of the EZH2-EED complex thus represents a novel strategy for interfer...

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Foilsithe in:Acta Pharmacol Sin
Main Authors: Zhu, Mao-rong, Du, Dao-hai, Hu, Jun-chi, Li, Lian-chun, Liu, Jing-qiu, Ding, Hong, Kong, Xiang-qian, Jiang, Hua-liang, Chen, Kai-xian, Luo, Cheng
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2018
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800469/
https://ncbi.nlm.nih.gov/pubmed/28858300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.59
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