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Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
Aberrant activity of enhancer of zeste homolog 2 (EZH2) is associated with a wide range of human cancers. The interaction of EZH2 with embryonic ectoderm development (EED) is required for EZH2's catalytic activity. Inhibition of the EZH2-EED complex thus represents a novel strategy for interfer...
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| Udgivet i: | Acta Pharmacol Sin |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5800469/ https://ncbi.nlm.nih.gov/pubmed/28858300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.59 |
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